Cannabinoids interact with different cannabinoid receptors in the body, sometimes in tandem and sometimes in competition.
In the periphery of the body, reduction of inflammation and neuropathic injury has been primarily ascribed to the activation of CB2. CB2 receptors are present in the peripheral nerves, as well as within the inflamed linings of the joints and skin.
Unlike classical receptors that are imbedded in the cellular membrane and exert their actions via activation of signalling cascades within the cell, PPARg directly affects expression of genes involved in inflammation.
One day, it is hoped that we have enough information about the action of cannabinoid receptors and the interplay between cannabinoids, that we can more specifically control pain and inflammation using cannabis medicine.